Resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, Venlafaxine

Resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, Venlafaxine

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New daily persistent headache is a continuous, unremitting headache, notorious for its unresponsiveness MASCARA BLACK BROWN #1310 to aggressive medical interventions.The underlying pathophysiology of new daily persistent headache is poorly understood resulting in unending, chronic pain.However, a prior study identified elevated tumor necrosis factor alpha within the cerebral spinal fluid of new daily persistent headache patients.Herein, we report on a patient who suffered with headache for 6 years failing to respond to over 20 different medical treatments, but found drastic improvement and eventual resolution with Venlafaxine.

This drug binds to the 5-HT 2A receptor inhibiting tumor necrosis XMAS WALL ART factor alpha signaling.Therefore, we hypothesize a chronic inflammatory mechanism driving new daily persistent headache pathology.